Andarine (GTx-007, S-4)
CAS Number: 401900-40-1
Molar mass 441.357 g/mol
Appearance: White to Off-White Powder
Use: As S4 has both anabolic and androgenic effects in muscle tissue, it will not only help with fat loss, but maintain and even increase muscle mass when cutting.
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
Andarine is an orally active partial agonist for androgen receptors.without producing any reduction in muscle mass or anti-androgenic side effects.
Uses of S-4:
Losing Bodyfat (Cutting)
Cutting is the environment where S-4 truly shines.
Certain steroids are considered “cutting” steroids such as Winstrol and Anavar. These steroids don’t offer too much in large gains in
muscle mass but are very effective in leaning out the body. The SARM S-4 has very similar properties.
The presence of androgen receptors in human preadipocytes and adipocytes suggests that androgens may contribute, through regulation of their own receptors, to the control of adipose tissue development. As S-4 shows this binding affinity to the AR, it demonstrates the similar fat burning effects. S-4 also shows a decrease in LPL (lipoprotein lipase) which is an enzyme that causes lipid accumulation.
S-4 also fits into a cutting protocol for the concurrent reduction in body fat with maintenance of muscle mass in a hypocaloric environment.
One of the most disheartening outcomes of cutting is the loss hard earned muscle mass. The drop in metabolic rate and hormone levels (T3, IGF, Testosterone etc) with the lack of calories is a perfect catabolic environment for loss of muscle tissue.
S-4 Dosage for cutting
A 50mg dosing protocol for 6-8 weeks is ideal for cutting purposes for the majority of users.
However due to the vision side effects, if running at these doses some like to follow a 5 on 2 off protocol where S4 is used for 5 days followed by a 2 day break (then this cycle is repeated).
Dosage for Strength gains and Lean mass gains
Due to its androgenicity in muscle tissue, S-4 is a good agent for increases in strength without bloat and large increases in weight.
Dosing at 50mg+ is the sweet spot for such gains.
Also due to its anabolic nature, these strength gains will come with associated gains in lean mass, albeit smaller than other more anabolic SARMS such as Ostarine.
1/3 as androgenic as testosterone in muscle tissue.
Anabolic at doses above 50mg
Great for strength
Great for muscle hardness
Great for enhanced vascularity
Great for endurance (aerobic or anaerobic)
Accelerated fat loss above 50mg
Joint healing effects
Half life of 4 hours
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